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Invitrogen™ CD49b (Integrin alpha 2) Monoclonal Antibody (AK7)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA543998
This item is not returnable.
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Description
This antibody recognizes an extracellular epitope of CD49b, a 160-165 kDa alpha subunit of VLA-2 integrin complex expressed on platelets, megakaryocytes, activated T and B cells, monocytes, epithelial cells, endothelial cells and fibroblasts.
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Specifications
CD49b (Integrin alpha 2) | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P17301 | |
Itga2 | |
Human platelets. | |
100 μg | |
Primary | |
Human, Monkey | |
Antibody | |
IgG1 |
ELISA, Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry | |
AK7 | |
Unconjugated | |
Itga2 | |
alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2 | |
Mouse | |
Protein A | |
RUO | |
3673 | |
4°C, do not freeze | |
Liquid |
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