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CD49d Mouse, anti-Rat, R718, Clone: MRA4-1, BD OptiBuild™

Catalog No. BDB752239 Shop All BD Biosciences Products
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BDB752239 50 μg
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Catalog No. BDB752239 Supplier BD Biosciences Supplier No. 752239
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Description

Mouse Monoclonal Antibody

The MRα4-1 antibody reacts with the integrin α4 chain, which is expressed as a heterodimer with either of two β chains, β1 or β7. The α4β1 integrin (VLA-4, CD49d/CD29) is expressed on peripheral T and B lymphocytes, thymocytes, and monocytes| while the α4β7 integrin (LPAM-1) is expressed on peripheral lymphocytes. These integrins mediate a variety of cell-cell and cell-matrix interactions, recognizing the ligands CD106 (VCAM-1), MAdCAM-1, and fibronectin. It has been reported that soluble mAb MRα4-1 partially inhibits in vitro binding of VCAM-1 and mast cells to fibronectin and inhibits the enhanced degranulation of IgE-sensitized RBL-2H3 basophilic leukemia cell line induced on fibronectin-coated plates. Furthermore, plate-bound MRα4-1 antibody enhances the degranulation of IgE-sensitized RBL-2H3 cells| and subcutaneous injection of MRα4-1 mAb, along with anti-CD49e and anti-CD61 antibodies, inhibits experimentally induced passive cutaneous anaphylaxis.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD49d
Applications Flow Cytometry
Classification Monoclonal
Clone MRA4-1
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Rat
Content And Storage Refrigerate Upon Arrival
Form Liquid
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