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  6. CD54 Hamster anti-Mouse, FITC, Clone: 3E2, BD

CD54 Hamster anti-Mouse, FITC, Clone: 3E2, BD

Catalog No. BDB561898 Shop All BD Biosciences Products
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0.5 mg
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Catalog No. Quantity
BDB561898 0.1 mg
BDB553252 0.5 mg
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Catalog No. BDB561898 Supplier BD Biosciences Supplier No. 561898

Description

Hamster Monoclonal Antibody

The 3E2 antibody reacts with CD54 (ICAM-1), a 95-kDa member of the Ig superfamily found on lymphocytes, vascular endothelium, high endothelial venules, epithelial cells, macrophages, and dendritic cells. ICAM-1 is a ligand for LFA1 (CD11a/CD18) and Mac-1 (CD11b/CD18). Its expression is upregulated upon stimulation by inflammatory mediators such as cytokines and LPS. Studies with mouse Icam1-transfected antigen-presenting cells, with CD54-blocking antibodies, and in CD54-deficient mice indicate that CD54 participates in inflammatory reactions and antigen-specific immune responses. In addition, there is evidence that CD54 is a receptor involved in MHC-non-restricted responses to weakly immunogenic tumor cells. The 3E2 antibody has been reported to block in vitro and in vivo intracellular adhesion events involved in immune responses.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD54
Applications Flow Cytometry
Classification Monoclonal
Clone 3.00E+02
Concentration 0.5mg/mL
Conjugate FITC
Description ICAM-1; Icam1; Intercellular adhesion molecule 1; Ly-47; MALA-2; MyD10
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Hamster
Immunogen Not reported
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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For Research Use Only.

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