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Invitrogen™ CD55 Monoclonal Antibody (RDII-24)
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Catalog No. FERMA549017
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100 μg
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Catalog No. Quantity
FERMA549017 100 μg
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Catalog No. FERMA549017 Supplier Invitrogen™ Supplier No. MA549017
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Description

Mouse Monoclonal Antibody

CD55 Monoclonal Antibody for Flow, Functional Assay, IHC (F), Inhibition, Western Blot

CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can regulate complement when bound to CD97. In tumors, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis. CD55 is a 70 kDa glycoprotein (in erythrocytes) anchored in the membrane by glycosylphosphatidylinositol tail. In other cells, the apparent molecular weight is somewhat larger for CD55 and has a substantial content of O-glycans. CD55 binds to activated C4b or C3b complement fragments on the cell surface, preventing the assembly and accelerating the decay of both classical and alternative pathways. CD55 carries the Cromer related blood group antigens. Two alternatively spliced transcripts encoding CD55 have been identified, and the predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. CD55 has been studied to have a role in prostate cancer growth and survival.
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Specifications

Antigen CD55
Applications Flow Cytometry, Functional Assay, Inhibition Assays, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone RDII-24
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene CD55
Gene Alias CD55; CD55 antigen; CD55 molecule (Cromer blood group); CD55 molecule, decay accelerating factor for complement; CD55 molecule, decay accelerating factor for complement (Cromer blood group); Cd55a; Complement decay-accelerating factor; complement decay-accelerating factor, GPI-anchored; complement-glycosylphosphatidylinositol; CR; CROM; Cromer blood group; Daf; Daf1; DAF-GPI; decay accelarating factor 1; decay accelerating factor 1; decay accelerating factor GPI-form; decay-accelarating factor; glycosylphophatidylinositol-anchored form; GPI anchor addition signal; GPI-DAF; RP11-357P18.1; TC
Gene Symbols CD55
Host Species Mouse
Immunogen NIH-3T3 cells expressing GPI-anchored rat DAF.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64036
Target Species Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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