Invitrogen™ CD56 Polyclonal Antibody

Catalog No.	Quantity
PIPA588353	100 μL

Catalog No. PIPA588353 Supplier Invitrogen™ Supplier No. PA588353

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LEFILVQADT PSSPSIDQVE PYSSTAQVQF DEPEATGGVP ILKYKAEWRA VGEEVWHSKW YDAKEASMEG IVTIVGLKPE TTYAVRLAAL NGKGLGEISA ASEFKTQPVQ GEPSAPKLEG QMGEDGNSIK VNLIKQDDGG SPIRHYLVRY RALSSEWKPE IRLPSGSDHV MLKSLDWNAE YEVYVVAENQ QGKSKAAHFV FRTSAQPTAI PANGSPTSGL S; Positive Samples: HT-1080, SW480, 293T, LO2, Mouse brain; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor, Single-pass type I membrane protein.

CD56, also known as neural cell adhesion molecule (NCAM), is a highly glycosylated transmembrane glycoprotein of the immunoglobulin family. It plays a crucial role in cell adhesion, migration, axonal growth, pathfinding, and synaptic plasticity. CD56 is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa and is involved in homotypic adhesion of neural cells. It mediates interactions by binding extracellular matrix components such as laminin and integrins, with polysialic modification reducing CD56-mediated adhesion. In the hematopoietic system, CD56 is expressed on natural killer (NK) cells and a subset of T cells known as NKT cells. It is also found on most neuroectodermal-derived cell lines, tissues, and neoplasms, including retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma. CD56 serves as a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms, highlighting its importance in both neural and immune system functions.

Specifications

• Antigen: CD56
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.38 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Ncam1
• Gene Accession No.: P13591, P13595
• Gene Alias: adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
• Gene Symbols: Ncam1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-720 of human NCAM1 (NP_8519962).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17967, 4684
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG