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CD56 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501980475
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100 μL
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50-198-0475 100 μL
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Catalog No. 50-198-0475 Supplier Bioss Supplier No. BS0736R
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Description

Rabbit Polyclonal Antibody

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

Specifications

Antigen CD56
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Ncam1
Gene Accession No. P13591
Gene Alias adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; CD56; CD-56; CD56 140 kDa isoform; E NCAM; E-NCAM; MSK39; N CAM1; Ncam; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
Gene Symbols Ncam1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CD56.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4684
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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