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Invitrogen™ CD58 Monoclonal Antibody (MEM-63), APC

Catalog No. PIMA174271
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100 Tests
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Catalog No. Quantity
PIMA174271 100 Tests
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Catalog No. PIMA174271 Supplier Invitrogen™ Supplier No. MA174271

Description

Mouse Monoclonal Antibody

Store product undiluted at 4°C in the dark. For FACS analysis, use 20 μL of the working dilution to label 1x10^6 cells in 100 μL. Mouse anti Human CD58 antibody, clone MEM-63 recognizes human CD58, also known as LFA-3. CD58 is a membrane glycoprotein of approximately 55-70 kDa.

CD58 is a member of the immunoglobulin superfamily and exists both as a transmembrane protein and a GPI-linked extracellular protein, with cells capable of expressing both forms concurrently. Additionally, soluble CD58 has been detected in serum, urine, and synovial fluid, particularly in patients with rheumatoid arthritis. CD58 is widely expressed on non-hematopoietic and most hematopoietic cells. CD58 serves as a ligand for the CD2 protein on T lymphocytes, playing a crucial role in adhesion and activation of T cells. The interaction between CD58 and CD2 initiates a signaling pathway that includes phosphorylation and leads to cytokine release. This interaction is important for T cell activation, cytokine production, cytotoxicity, and adhesion to various cell types. The protein is localized to the plasma membrane, and alternatively spliced transcript variants have been described, indicating diverse functional roles. CD58's involvement in immune responses highlights its significance in both normal physiological processes and disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD58
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-63
Concentration 0.1 mg/mL
Conjugate APC
Formulation TBS with 0.09% sodium azide
Gene CD58
Gene Accession No. P19256
Gene Alias Ag3; CD305; CD58; CD58 antigen; CD58 antigen, (lymphocyte function-associated antigen 3); CD58 molecule; FLJ23181; FLJ43722; LAIR1; LAIR-1; LFA3; LFA-3; Lymphocyte function-associated antigen 3; membrane receptor; RP5-1086K13.2; surface glycoprotein LFA-3
Gene Symbols CD58
Host Species Mouse
Immunogen Proprietary sequence.
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 965
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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