Invitrogen™ CD58 Monoclonal Antibody (TS2/9)

Catalog No.	Quantity
ENMA5800	200 μg

Catalog No. ENMA5800 Supplier Invitrogen™ Supplier No. MA5800

Description

Mouse Monoclonal Antibody

MA5800 targets CD58 in WB, FACS, IF, IHC(F), IP, and Neu applications and shows reactivity with Human and Mouse samples. The MA5800 immunogen is human Leukocyte Function Antigen-3. MA5800 detects CD58 which has a predicted molecular weight of approximately 24 kDa. This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains an endotoxin concentration of less than or equal to 10 endotoxin units per milligram (EU/mg).

CD58 is a member of the immunoglobulin superfamily and exists both as a transmembrane protein and a GPI-linked extracellular protein, with cells capable of expressing both forms concurrently. Additionally, soluble CD58 has been detected in serum, urine, and synovial fluid, particularly in patients with rheumatoid arthritis. CD58 is widely expressed on non-hematopoietic and most hematopoietic cells. CD58 serves as a ligand for the CD2 protein on T lymphocytes, playing a crucial role in adhesion and activation of T cells. The interaction between CD58 and CD2 initiates a signaling pathway that includes phosphorylation and leads to cytokine release. This interaction is important for T cell activation, cytokine production, cytotoxicity, and adhesion to various cell types. The protein is localized to the plasma membrane, and alternatively spliced transcript variants have been described, indicating diverse functional roles. CD58's involvement in immune responses highlights its significance in both normal physiological processes and disease states.

Specifications

• Antigen: CD58
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: TS2/9
• Concentration: 1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: CD58
• Gene Accession No.: P19256
• Gene Alias: Ag3; CD305; CD58; CD58 antigen; CD58 antigen, (lymphocyte function-associated antigen 3); CD58 molecule; FLJ23181; FLJ43722; LAIR1; LAIR-1; LFA3; LFA-3; Lymphocyte function-associated antigen 3; membrane receptor; RP5-1086K13.2; surface glycoprotein LFA-3
• Gene Symbols: CD58
• Host Species: Mouse
• Immunogen: Human Leukocyte Function Antigen-3.
• Purification Method: Protein A
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 965
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1