Invitrogen™ CD58 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596389

Catalog No. PIPA596389

Description

Immunogen sequence: NVTFHVPSNV PLKEVLWKKQ KDKVAELENS EFRAFSSFKN RVYLDTVSGS LTIYNLTSSD EDEYEMESPN ITDTMKFFLY VLESLPSPTL TCALTNGSIE VQCMIPEHYN SHRGLIMYSW DCPMEQCKRN STSIYFKMEN DLPQKIQCTL SNPLFNTTSS IILTTCIPSS GHSRHRYALI P; Positive Samples: MCF7, 293T; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor, Single-pass type I membrane protein.

CD58 is a member of the immunoglobulin superfamily and exists both as a transmembrane protein and a GPI-linked extracellular protein, with cells capable of expressing both forms concurrently. Additionally, soluble CD58 has been detected in serum, urine, and synovial fluid, particularly in patients with rheumatoid arthritis. CD58 is widely expressed on non-hematopoietic and most hematopoietic cells. CD58 serves as a ligand for the CD2 protein on T lymphocytes, playing a crucial role in adhesion and activation of T cells. The interaction between CD58 and CD2 initiates a signaling pathway that includes phosphorylation and leads to cytokine release. This interaction is important for T cell activation, cytokine production, cytotoxicity, and adhesion to various cell types. The protein is localized to the plasma membrane, and alternatively spliced transcript variants have been described, indicating diverse functional roles. CD58's involvement in immune responses highlights its significance in both normal physiological processes and disease states.

Specifications

• Antigen: CD58
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD58
• Gene Alias: Ag3; CD305; CD58; CD58 antigen; CD58 antigen, (lymphocyte function-associated antigen 3); CD58 molecule; FLJ23181; FLJ43722; LAIR1; LAIR-1; LFA3; LFA-3; Lymphocyte function-associated antigen 3; membrane receptor; RP5-1086K13.2; surface glycoprotein LFA-3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 965
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.36 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P19256
• Gene Symbols: CD58
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-220 of human CD58 (NP_0017701).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG