Invitrogen™ CD58 Recombinant Rabbit Monoclonal Antibody (083), PE

Catalog No.	Quantity
PIMA546752	100 Tests

Catalog No. PIMA546752

Supplier: Invitrogen™ MA546752

Description

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD58 (Met1-Arg215) and conjugated with PE under optimum conditions, the unreacted PE was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD58 is a member of the immunoglobulin superfamily and exists both as a transmembrane protein and a GPI-linked extracellular protein, with cells capable of expressing both forms concurrently. Additionally, soluble CD58 has been detected in serum, urine, and synovial fluid, particularly in patients with rheumatoid arthritis. CD58 is widely expressed on non-hematopoietic and most hematopoietic cells. CD58 serves as a ligand for the CD2 protein on T lymphocytes, playing a crucial role in adhesion and activation of T cells. The interaction between CD58 and CD2 initiates a signaling pathway that includes phosphorylation and leads to cytokine release. This interaction is important for T cell activation, cytokine production, cytotoxicity, and adhesion to various cell types. The protein is localized to the plasma membrane, and alternatively spliced transcript variants have been described, indicating diverse functional roles. CD58's involvement in immune responses highlights its significance in both normal physiological processes and disease states.

Specifications

• Antigen: CD58
• Applications: Flow Cytometry
• Classification: Recombinant Monoclonal
• Clone: 083
• Concentration: 100 μg/mL
• Conjugate: PE
• Formulation: PBS with 0.5% BSA and 0.09% sodium azide
• Gene: CD58
• Gene Accession No.: P19256
• Gene Alias: Ag3; CD305; CD58; CD58 antigen; CD58 antigen, (lymphocyte function-associated antigen 3); CD58 molecule; FLJ23181; FLJ43722; LAIR1; LAIR-1; LFA3; LFA-3; Lymphocyte function-associated antigen 3; membrane receptor; RP5-1086K13.2; surface glycoprotein LFA-3
• Gene Symbols: CD58
• Host Species: Rabbit
• Immunogen: Recombinant protein ecoding Human CD58 (Met1-Arg215).
• Purification Method: Protein A
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 965
• Target Species: Human
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov