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CD59 Mouse anti-Human, Clone: MACIF/629, Abnova™

Catalog No. 89933843 Shop All Abnova Corporation Products
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89-933-843 100 μg
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Catalog No. 89-933-843 Supplier Abnova Corporation Supplier No. MAB13475
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Description

Mouse monoclonal antibody raised against full length recombinant human CD59.

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]

Specifications

Antigen CD59
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone MACIF/629
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against full length recombinant human CD59.
Dilution Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Alias 16.3A5/1F5/EJ16/EJ30/EL32/FLJ38134/FLJ92039/G344/HRF-20/HRF20/MAC-IP/MACIF/MEM43/MGC2354/MIC11/MIN1/MIN2/MIN3/MIRL/MSK21/p18-20
Gene Symbols CD59
Host Species Mouse
Immunogen Recombinant protein corresponding to full length human CD59.
Purification Method Protein G purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 966
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG1 κ
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