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Invitrogen™ CD6 Monoclonal Antibody (IM348), PE, eBioscience™
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Catalog No. 5010179
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25 μg
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Catalog No. Quantity
50-101-79 25 μg
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Catalog No. 50-101-79 Supplier Invitrogen™ Supplier No. 12006180
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Description

Rat Monoclonal Antibody

The monoclonal antibody IM348 recognizes mouse CD6, a transmembrane glycoprotein of the scavenger receptor family. The extracellular domain contains three scavenger receptor cysteine rich (SRCR) domains, a transmembrane region and a cytoplasmic domain of variable length depending on the isoform. CD6 is expressed on most T lymphocytes. Expression between human and mouse is slightly different. In mice B cells in the spleen do not have CD6, while humans express it on a subset of B lymphocytes. The CD6 ligand is CD166, also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM). Through interactions with CD166 or homotypic CD6-CD6, a role exists in adhesion and migration during organogenesis. The intracellular domain of CD6 is constitutively phosphorylated, suggesting a role in T cell activation and signaling. In humans depletion of CD6-expressing cells increases graft versus host tolerance in transplants. Applications Reported: This IM348 antibody has been reported for use in flow cytometric analysis. Applications Tested: This IM348 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the ass...

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.
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Specifications

Antigen CD6
Applications Flow Cytometry
Classification Monoclonal
Clone IM348
Concentration 0.2 mg/mL
Conjugate PE
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD6
Gene Accession No. Q61003
Gene Alias Cd6; CD6 antigen; CD6 antigen, Tp120; Cd6 molecule; FLJ44171; OX52; Soluble CD6; T12; T-cell differentiation antigen CD6; TP120
Gene Symbols CD6
Host Species Rat
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12511
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a
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