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Invitrogen™ CD61 (Integrin beta 3) Monoclonal Antibody (M581)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA547721
Description
This antibody detects a 100kDa* protein corresponding to the molecular mass of Integrin beta3 on SDS-PAGE immunoblots of human platelets and endothelial cells (HUVEC).
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets and their precursors. CD61 antigen plays a role in platelet aggregation and also as a receptor for fibrinogen, fibronectin, von Willebrand factor and vitronectrin. CD61 is a 105 kDa glycoprotein that associates with either the alpha 11b integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, Von Willebrand Factor, vitronectin and thrombospondin. The CD61 protein product is composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. CD61 is found along with the alpha IIb chain in platelets. Like other integrins, CD61 is known to participate in cell adhesion as well as cell-surface mediated signaling. Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
Specifications
CD61 (Integrin beta 3) | |
Monoclonal | |
0.08 mg/mL | |
PBS with 1 mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
O54890, P05106 | |
ITGB3 | |
Clone M581 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin beta3. This sequence has high homology with rat and mouse Integrin beta3, and has low homology to other integrin family members. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
Western Blot, Immunocytochemistry | |
M581 | |
Unconjugated | |
ITGB3 | |
antigen CD61; BDPLT16; BDPLT2; beta3 integrin; CD61; EGK_08849; glycoprotein GPIIIa; glycoprotein IIIa; GP3A; GPIIIa; GT; INGRB3; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin beta-3 subunit; integrin subunit beta 3; integrin, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITGB3; platelet glycoprotein IIIa; platelet glycoprotein IIIa integrin subunit beta 3; platelet gpIIIa; platelet membrane glycoprotein IIIa | |
Mouse | |
Protein A | |
RUO | |
16416, 29302, 3690 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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