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CD61 Mouse Anti-Rat, Brilliant Violet 510, Clone: F11, BD Optibuild™

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BDB744456 50 μg
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Catalog No. BDB744456 Supplier BD Biosciences Supplier No. 744456
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Description

Mouse Monoclonal Antibody

The F11 monoclonal antibody specifically recognizes integrin 3 chain (CD61), which associates with the integrin v chain (CD51), to form the vitronectin receptor found on endothelial cells, myeloid cells, and osteoclasts, and with the IIb chain (CD41) on platelets and megakaryocytes. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. The F11 antibody reportedly blocks the in vitro attachment of osteoclasts to several ligands. Weak F11 antibody reactivity with human osteoclasts, megakaryocytes, and platelets has also been reported.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD61
Classification Monoclonal
Clone F11
Concentration 0.2mg/mL
Conjugate Brilliant Violet 510
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Integrin β3 chain, Itgb3, Integrin beta-3
Host Species Mouse
Immunogen Rat (Sprague-Dawley) bone cell suspensions
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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