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CD62P (P-Selectin) Mouse anti-Human, Clone: AK-4, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$53.75 - $107.00

Specifications

Antigen CD62P (P-Selectin)
Clone AK-4
Target Species Human
Conjugate Unconjugated
Isotype IgG1, kappa
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-126-75 Non-distribution product as customer accommodation.
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Invitrogen
14062880
25 μg Each for $53.75
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50-126-76 Non-distribution product as customer accommodation.
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Invitrogen
14062882
100 μg Each for $107.00
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Description

Description

Description: The AK-4 monoclonal antibody reacts with human CD62P, a 140 kDa transmembrane glycoprotein also known as P-Selectin. Upon activation, CD62P is rapidly transported from its cytoplasmic stores in the Weibel-Palade bodies of endothelial cells or the alpha-granules of platelets to the surface. CD62P initiates the adhesive interaction between endothelial cells and neutrophils and monocytes during the inflammatory reaction and is also involved in the interaction of platelets with monocytes and neutrophils. Applications Reported: The AK-4 antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining of frozen tissue sections. AK-4 has also been reported in blocking adhesion of platelets in in vitro assays. (Please use Functional Grade purified AK-4, cat. 16-0628, in functional assays.). Applications Tested: This AK-4 antibody has been tested by flow cytometric analysis of resting and thrombin-activated human platelets. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered. P-selectin is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate.
Specifications

Specifications

CD62P (P-Selectin)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C
AK-4
Unconjugated
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

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