CD63 Antibody (LAMP3/2788) - Azide and BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP278813

Catalog No. NB002965

Description

CD63 Monoclonal specifically detects CD63 in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

• Antigen: CD63
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: 10mM PBS.
• Gene Symbols: CD63
• Immunogen: Recombinant human CD63 protein fragment (around aa100-197) (exact sequence is proprietary) (Uniprot: P08962 )
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This monoclonal antibody recognizes protein of 26kDa-60kDa, which is identified as CD63. Its epitope is different from that of monoclonal antibody LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
• Content And Storage: Store at 4°C.
• Isotype: IgG2b κ

• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Peptide Array
• Clone: LAMP3/2788
• Dilution: Western Blot 1-2 μg/mL, Immunohistochemistry 1-2 μg/mL, Immunohistochemistry-Paraffin 1-2 μg/mL, Protein Array
• Gene Alias: CD63 antigen, CD63 antigen (melanoma 1 antigen), CD63 molecule, Granulophysin, LAMP-3, Lysosomal-associated membrane protein 3, ME491, melanoma 1 antigen, Melanoma-associated antigen ME491, melanoma-associated antigen MLA1, MLA1lysosome-associated membrane glycoprotein 3, Ocular melanoma-associated antigen, OMA81H, Tetraspanin-30, tspan-30, TSPAN30granulophysin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Autophagy, Cancer, Cardiovascular Biology, Cytokine Research, Immunology, Innate Immunity, Lysosome Markers, Metastasis
• Gene ID (Entrez): 967
• Target Species: Human, Mouse
• Form: Purified