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Invitrogen™ CD68 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA589134
Description
Positive Samples: Mouse fat, Mouse skin, Rat skin; Cellular Location: Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Single-pass type I membrane protein Immunogen sequence: NDCPHKKSAT LLPSFTVTPT VTESTGTTSH RTTKSHKTTT HRTTTTGTTS HGPTTATHNP TTTSHGNVTV HPTSNSTATS QGPSTATHSP ATTSHGNATV HPTSNSTATS PGFTSSAHPE PPPPSPSPSP TSKETIGDYT WTNGSQPCVH LQAQIQIRVM YTTQGGGEAW GISVLNPNKT KVQGSCEGAH PHLLLSFPYG HLSFGFMQDL QQKVVYLSYM AVEYNVSFPH AAQWTFSAQN ASLRDLQAPL GQSFSCSNSS IILSPAVHLD LLSLRLQAAQ LPHTGVFGQS FSCPSDRS.
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
Specifications
CD68 | |
Polyclonal | |
Unconjugated | |
Cd68 | |
CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen | |
Rabbit | |
Affinity Chromatography | |
RUO | |
968 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
0.91 mg/mL | |
PBS with 50% glycerol and 0.09% sodium azide; pH 7.3 | |
P34810 | |
Cd68 | |
A synthetic peptide corresponding to a sequence within amino acids 22-319 of human CD68 (NP_0012422). | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
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