CD7 Antibody (B-F12), Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2447990.2MG

Catalog No. NBP24479902

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD7 Monoclonal antibody specifically detects CD7 in Human, Porcine, Guinea Pig samples. It is validated for Flow Cytometry, SDS-Page, Immunofluorescence.

Specifications

• Antigen: CD7
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
• Gene Alias: CD7 antigen, CD7 antigen (p41), CD7 molecule, GP40T-cell surface antigen Leu-9, LEU-9, T-cell antigen CD7, T-cell leukemia antigen, Tp40, TP41p41 protein
• Host Species: Mouse
• Molecular Weight of Antigen: 40 kDa
• Quantity: 0.2 mg
• Research Discipline: Cytokine Research, Signal Transduction
• Gene ID (Entrez): 924
• Target Species: Human, Pig, Guinea Pig
• Form: Purified

• Applications: Flow Cytometry, SDS-Page, Immunofluorescence
• Clone: B-F12
• Conjugate: Unconjugated
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Symbols: CD7
• Immunogen: Chronic Lymphoid Leukemia cells (CLL)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
• Content And Storage: Store at 4C.
• Isotype: IgG2a κ

For Research Use Only