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Invitrogen™ CD7 Monoclonal Antibody (21)
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Catalog No. PIMA541062
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100 μL
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PIMA541062 100 μL
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Catalog No. PIMA541062 Supplier Invitrogen™ Supplier No. MA541062
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Description

Mouse Monoclonal Antibody

CD7 Monoclonal Antibody for Flow, IHC (P), Western Blot

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD7
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 21
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 10% trehalose, 0.02% Tween 80 and no preservative; pH 7.0
Gene CD7
Gene Accession No. P09564
Gene Alias Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Gene Symbols CD7
Host Species Mouse
Immunogen Human CD7 Plasmid.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 924
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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