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  6. Invitrogen™ CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), NovaFluor™ Blue 660-120S, eBioscience™, Invitrogen™ 

Invitrogen™ CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), NovaFluor™ Blue 660-120S, eBioscience™, Invitrogen™

Catalog No. H018T02B08A
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H018T02B08A 25 Tests
H018T03B08A 100 Tests
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Catalog No. H018T02B08A Supplier Invitrogen™ Supplier No. H018T02B08A
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Description

Mouse Monoclonal Antibody

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.
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Specifications

Antigen CD7
Applications Flow Cytometry
Classification Monoclonal
Clone eBio124-1D1 (124-1D1)
Concentration 0.8 μg/Test
Conjugate NovaFluor Blue 660-120S
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD7
Gene Accession No. P09564
Gene Alias Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Gene Symbols CD7
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 924
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG1 κ
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