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Invitrogen™ CD7 Polyclonal Antibody
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Catalog No. PIPA5117100
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100 μL
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PIPA5117100 100 μL
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Catalog No. PIPA5117100 Supplier Invitrogen™ Supplier No. PA5117100
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Description

Rabbit Polyclonal Antibody

Positive Samples: Raji, Jurkat, THP-1 Immunogen sequence: AQEVQQSPHC TTVPVGASVN ITCSTSGGLR GIYLRQLGPQ PQDIIYYEDG VVPTTDRRFR GRIDFSGSQD NLTITMHRLQ LSDTGTYTCQ AITEVNVYGS GTLVLVTEEQ SQGWHRCSDA PPRASALPAP PTGSALPDPQ TASALPDPPA ASALP.

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD7
Applications ELISA, Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.79 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene CD7
Gene Accession No. P09564
Gene Alias Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
Gene Symbols CD7
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 26-180 of human CD7 (NP_0061281).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 303747, 924
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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