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Invitrogen™ CD7 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA532332
Description
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.
CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.
Specifications
CD7 | |
Polyclonal | |
PBS with 1% BSA and 0.1% sodium azide; pH 7.6 | |
P09564 | |
CD7 | |
Synthetic peptide derived from internal region of human CD7 protein. | |
500 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin) | |
Unconjugated | |
CD7 | |
Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
924 | |
4°C | |
Liquid |
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