Invitrogen™ CD70 Recombinant Rat Monoclonal Antibody (TAN1-6)

Rat Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA548154

Catalog No. PIMA548154

Description

Specificity: This antibody is specific for murine CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.

Specifications

• Antigen: CD70
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: O55237
• Gene Symbols: Cd70
• Immunogen: This antibody was raised by immunising LOU rats with soluble recombinant CD70:Fc fusion protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Inhibition Assays, Western Blot, Immunocytochemistry
• Clone: TAN1-6
• Conjugate: Unconjugated
• Gene: Cd70
• Gene Alias: CD27 ligand; Cd27l; CD27-L; CD27LG; CD70; CD70 antigen; Cd70 molecule; Ki-24 antigen; surface antigen CD70; Tnfsf7; TNLG8A; tumor necrosis factor (ligand) superfamily, member 7; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7
• Host Species: Rat
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 21948
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid