CD71 Mouse anti-Human, PE, Clone: M-A712, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB561938	BD Biosciences 561938	25 Tests
BDB555537	BD Biosciences 555537	100 Tests

Description

The M-A712 monoclonal antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surface.

Specifications

• Antigen: CD71
• Applications: Flow Cytometry
• Conjugate: PE
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Isotype: IgG2a κ
• Purification Method: Affinity Purified
• Description: TFR; TFRC; Trfr; TfR1; Transferrin receptor protein 1

• Clone: M-A712
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Immunogen: T-CLL and Jurkat Cells
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.