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Invitrogen™ CD72 Monoclonal Antibody (3F3)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119248
Description
This antibody recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes differentiation with the exception of plasma cells; it is also present on follicular dendritic cells.
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
Specifications
CD72 | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P21854 | |
CD72 | |
Normal human lymphocytes from a lymph node. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
Flow Cytometry, Immunoprecipitation | |
3F3 | |
Unconjugated | |
CD72 | |
B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9 | |
Mouse | |
Protein A | |
RUO | |
971 | |
4°C, do not freeze | |
Liquid |
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