Invitrogen™ CD72 Monoclonal Antibody (3F3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119248

Catalog No. 01-676-012

Description

This antibody recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes differentiation with the exception of plasma cells; it is also present on follicular dendritic cells.

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.

Specifications

• Antigen: CD72
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P21854
• Gene Symbols: CD72
• Immunogen: Normal human lymphocytes from a lymph node.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: 3F3
• Conjugate: Unconjugated
• Gene: CD72
• Gene Alias: B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 971
• Content And Storage: 4°C, do not freeze
• Form: Liquid