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Invitrogen™ CD72 Polyclonal Antibody
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Catalog No. PIPA597292
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100 μL
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PIPA597292 100 μL
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Catalog No. PIPA597292 Supplier Invitrogen™ Supplier No. PA597292
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QVSQQLQQTN RVLEVTNSSL RQQLRLKITQ LGQSAEDLQG SRRELAQSQE ALQVEQRAHQ AAEGQLQACQ ADRQKTKETL QSEEQQRRAL EQKLSNMENR LKPFFTCGSA DTCCPSGWIM HQKSCFYISL TSKNWQESQK QCETLSSKLA TFSEIYPQSH SYYFLNSLLP NGGSGNSYWT GLSSNKDWKL TDDTQRTRTY AQSSKCNKVH KTWSWWTLES ESCRSSLPYI CEMTAFRFPD; Positive Samples: B-cell, Mouse liver, Mouse kidney, Rat liver, Rat kidney; Cellular Location: Membrane, Single-pass type II membrane protein.

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD72
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.28 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CD72
Gene Accession No. P21854, P21855
Gene Alias B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9
Gene Symbols CD72
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 120-359 of human CD72 (NP_0017731).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12517, 313498, 971
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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