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Invitrogen™ CD72 Polyclonal Antibody
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Catalog No. PIPA583732
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100 μL
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PIPA583732 100 μL
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Catalog No. PIPA583732 Supplier Invitrogen™ Supplier No. PA583732
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AQSQEALQVE QRAHQAAEGQ LQACQADRQK TKETLQSEEQ QRRALEQKLS NMENRLKPFF TCGSADTCCP SGWIMHQKSC FYISLTSKNW QESQKQCETL SSKLATFSEI YPQSHSYYFL NSLLPNGGSG NSYWTGLSSN KDWKLTD Highest antigen sequence indentity to the following orthologs: Rat - 39%, Mouse - 47%.

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD72
Applications Immunohistochemistry (Paraffin), Immunocytochemistry, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CD72
Gene Accession No. P21854
Gene Alias B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9
Gene Symbols CD72
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CD72. Recombinant protein control fragment (Product #RP-102969).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 971
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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