Invitrogen™ CD72 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583732

Catalog No. PIPA583732

Description

Immunogen sequence: AQSQEALQVE QRAHQAAEGQ LQACQADRQK TKETLQSEEQ QRRALEQKLS NMENRLKPFF TCGSADTCCP SGWIMHQKSC FYISLTSKNW QESQKQCETL SSKLATFSEI YPQSHSYYFL NSLLPNGGSG NSYWTGLSSN KDWKLTD.

CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.

Specifications

• Antigen: CD72
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD72
• Gene Alias: B-cell differentiation antigen CD72; CD72; CD72 antigen; Cd72 molecule; CD72b; CD72c; Ly-19; Ly32; Ly-32; LYB2; Lyb-2; Ly-m19; lymphocyte antigen 32; RP11-331F9.9
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 971
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry, Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P21854
• Gene Symbols: CD72
• Immunogen: Recombinant protein corresponding to Human CD72. Recombinant protein control fragment (Product #RP-102969).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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