CD74 Monoclonal Antibody (LN2), Invitrogen™

Catalog No.	Quantity
PIMA511911	500 μL

Catalog No. PIMA511911 Supplier Thermo Scientific Supplier No. MA511911

Description

Mouse Monoclonal Antibody

MA5-11911 targets CD74 in FACS, IF, IHC (P), and WB applications and shows reactivity with Human and Non-human primate samples. This antibody is not suitable for mouse BAF-3 cells in FACS analysis. The MA5-11911 immunogen is sU-DHL-4 lymphoma cells.

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

Specifications

• Antigen: CD74
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: LN2
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene: CD74
• Gene Accession No.: P04233
• Gene Alias: CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule; Cd74 molecule, major histocompatibility complex, class II invariant chain; class II-associated invariant chain peptide; CLIP; DHLAG; dinucleotide microsatellite; gamma chain of class II antigens; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA class II histocompatibility antigen gamma chain; HLADG; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; INVG34; MHC class II-associated invariant chain; MHC HLA-DR gamma chain; p33
• Gene Symbols: CD74
• Host Species: Mouse
• Immunogen: SU-DHL-4 lymphoma cells
• Purification Method: Protein G
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 972
• Target Species: Human, Non-human Primate
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ