CD8 Mouse anti-Human, Clone: CA-8, Abnova™

Mouse monoclonal antibody raised against full length native of human CD8.

Supplier:  Abnova Corporation MAB12451

Catalog No. 89-933-871

Description

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq]

Specifications

• Antigen: CD8
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene Alias: CD8/Leu2/MAL/p32
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen)
• Clone: CA-8
• Description: Mouse monoclonal antibody raised against full length native of human CD8.
• Formulation: Lyophilized from ascites fluid (1.2% sodium acetate, 2mg BSA, 0.01mg sodium azide)
• Gene Symbols: CD8A
• Immunogen: Native purified CD8 from human thymocytes.
• Regulatory Status: RUO
• Gene ID (Entrez): 925/926
• Content And Storage: Store at −20°C. After reconstitution with 1mLof 1.2% sodium acetate or neutral PBS and concentration will be 100μg/mL, store at −20°C. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2a