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MilliporeSigma™ CD8, Mouse, FITC, Clone: SK1,

Mouse Monoclonal Antibody

$188.00 - $1630.00

Specifications

Antigen CD8
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone SK1
Host Species Mouse
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Conjugate Price Quantity & Availability  
MABF1670MI View Documents MilliporeSigma™
MABF1670
25 tests FITC Each for $188.00
Add to cart
 
MABF1671MI View Documents MilliporeSigma™
MABF1671
100 tests FITC Each for $408.00
Add to cart
 
MABF1672MI View Documents MilliporeSigma™
MABF1672
500 tests FITC Each for $1,630.00
Add to cart
 
Description

Description

The SK1 antibody is specific for the 32-34kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The SK1 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. It is cross-reactive with CD8 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus. If used together with an alternative Anti-Human CD8a clone, RPA-T8, the SK1 antibody will not block binding of RPA-T8 to CD8a.
Specifications

Specifications

CD8
Monoclonal
Mouse
Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Stable for 1 year at 2°-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2°-8°C and protected from prolonged exposure to light. Do not freeze.
Primary
SK1
Purified
Flow Cytometry
RUO

For Research Use Only. Not for use in diagnostic procedures.

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