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CD8 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA516693
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500 μL
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PIPA516693 500 μL
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Catalog No. PIPA516693 Supplier Thermo Scientific Supplier No. PA516693

Description

Rabbit Polyclonal Antibody

PA5-16693 targets CD8 in IHC (P) applications and shows reactivity with Human samples. The PA5-16693 immunogen is synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 molecule.

CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide
Gene CD8B
Gene Accession No. P10966, P33706, P01732
Gene Alias CD8, Leu-2, MAL, p32, CD8a, CD8b, CD8alpha, CD8beta
Gene Symbols CD8A, CD8B
Host Species Rabbit
Immunogen Synthetic peptide sequence comprising the 13 C-terminal amino acids of the cytoplasmic domain of alpha chain of the CD8 molecule
Purification Method Affinity chromatography
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 403157, 926, 925
Target Species Canine, Human, Rhesus Monkey
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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