CD80 Mouse anti-Human, Clone: OTI2B11, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF501575

Catalog No. 50-166-0579

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

Specifications

• Antigen: CD80
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CD80
• Gene Alias: B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 941
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2B11
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P33681
• Gene Symbols: CD80
• Immunogen: Full length human recombit protein of human CD80 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a