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Invitrogen™ CD83 Polyclonal Antibody

Catalog No. PIPA596044
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PIPA596044 100 μL
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Catalog No. PIPA596044 Supplier Invitrogen™ Supplier No. PA596044

Description

Rabbit Polyclonal Antibody

Positive Samples: Jurkat, Mouse intestine; Cellular Location: Membrane, Single-pass type I membrane protein Immunogen sequence: TPEVKVACSE DVDLPCTAPW DPQVPYTVSW VKLLEGGEER METPQEDHLR GQHYHQKGQN GSFDAPNERP YSLKIRNTTS CNSGTYRCTL QDPDGQRNLS GKVILRVTGC PAQRKEETFK KYRA.

CD83 cell surface antigen is a 40-45kD glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express very low levels of CD83 after culture in agents such as Con A or PHA. In immunohistology, CD83 is shown to be expressed strongly by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres. CD83 is also expressed by Langerhan's cells in the skin. The CD83 antigen is a 186-amino-acid single-chain glycoprotein and this molecule is a member of the immunoglobulin superfamily that is composed of an extracellular V-type Ig-like single domain, a transmembrane region, and a short, 40-amino-acid cytoplasmic tail. CD83 antigen undergoes extensive post-translational glycosylation, since the determined Mr is twice the predicted size of the core protein. However, CD83+ cells have a unique cell surface immuno-phenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. CD83+ cells coexpress the highest levels of MHC class II molecules, when compared with other leucocyte lineages. They also co-express T cell markers (CD2, CD5), B cell markers (CD40, CD78), myeloid cell markers (CD13, CD33, CD36), cytokine receptors as well as other cell surface molecules. Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD83
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CD83
Gene Accession No. O88324, Q01151
Gene Alias B-cell activation protein; BL11; CD antigen CD83; CD83; CD83 antigen; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); CD83 molecule; cell surface protein HB15; cell-surface glycoprotein; HB15; hCD83; mCD83
Gene Symbols CD83
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 20-143 of human CD83 (NP_0042241).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12522, 361226, 9308
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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