Invitrogen™ CD85k (Gp49b) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596569

Catalog No. PIPA596569

Description

Immunogen sequence: QAGPLPKPTL WAEPGSVISW GNSVTIWCQG TLEAREYRLD KEESPAPWDR QNPLEPKNKA RFSIPSMTED YAGRYRCYYR SPVGWSQPSD PLELVMTGAY SKPTLSALPS PLVTSGKSVT LLCQSRSPMD TFLLIKERAA HPLLHLRSEH GAQQHQAEFP MSPVTSVHGG TYRCFSSHGF SHYLLSHPSD PLELIVSGSL EGPRPSPTRS VSTAAGPEDQ PLMPTGSVPH SGLRRHWE; Positive Samples: HL-60, Mouse liver, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: CD85k (Gp49b)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LILRB4
• Gene Alias: CD85 antigen-like family member K; CD85K; glycoprotein 49 B; glycoprotein 49b; gp49; Gp49b; GP49B2; HM18; ILT3; ILT-3; Immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin like receptor B4; leukocyte immunoglobulin-like receptor 5; Leukocyte immunoglobulin-like receptor subfamily B member 4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; leukocyte immunoglobulin-like receptor, subfamily B, member 4; leukocyte surface receptor; Lilrb4; LIR5; LIR-5; mast cell surface glycoprotein Gp49B; Monocyte inhibitory receptor HM18
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11006, 14728, 292594
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.1 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q64281, Q8NHJ6
• Gene Symbols: LILRB4, Lilrb4a
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-259 of human LILRB4 (NP_0012653552).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov