CD86 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA596112

Catalog No. PIPA596112

Description

Immunogen sequence: APLKIQAYFN ETADLPCQFA NSQNQSLSEL VVFWQDQENL VLNEVYLGKE KFDSVHSKYM GRTSFDSDSW TLRLHNLQIK DKGLYQCIIH HKKPTGMIRI HQMNSELSVL ANFSQPEIVP ISNITENVYI NLTCSSIHGY PEPKKMSVLL RTKNSTIEYD GIMQKSQDNV TELYDVSISL SVSFPDVTSN MTIFCILETD KTRLLSSPFS IELEDPQPPP DHIP Positive Samples: THP-1, SGC-7901; Cellular Location: Cell membrane, Single-pass type I membrane protein

CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

Specifications

• Antigen: CD86
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CD86
• Gene Alias: activation B7-2 antigen, B lymphocyte activation antigen B72, B7, B7.2, B70, B7-2, B-lymphocyte activation antigen B7-2, BU63, CD28 antigen ligand 2, Cd28l2, CD28LG2, CD86, CD86 antigen, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CD86 antigen precursor, CD86 molecule, CLS1, CTLA-4 counter-receptor B7.2, early T cell costimulatory molecule-1, early T-cell costimulatory molecule 1, Early T-cell co-stimulatory molecule 1, ETC-1, FUN-1, LAB72, Ly58, Ly-58, MB7, MB7-2, membrane glycoprotein, MGC34413, T-lymphocyte activation antigen CD86, TS/A-2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12524, 942
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 3.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
• Gene Accession No.: P42081, P42082
• Gene Symbols: CD86
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human CD86 (NP_7870584)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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