Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA596112

CD86 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA596112
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA596112 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA596112 Supplier Thermo Scientific Supplier No. PA596112

Description

Rabbit Polyclonal Antibody

Immunogen sequence: APLKIQAYFN ETADLPCQFA NSQNQSLSEL VVFWQDQENL VLNEVYLGKE KFDSVHSKYM GRTSFDSDSW TLRLHNLQIK DKGLYQCIIH HKKPTGMIRI HQMNSELSVL ANFSQPEIVP ISNITENVYI NLTCSSIHGY PEPKKMSVLL RTKNSTIEYD GIMQKSQDNV TELYDVSISL SVSFPDVTSN MTIFCILETD KTRLLSSPFS IELEDPQPPP DHIP Positive Samples: THP-1, SGC-7901; Cellular Location: Cell membrane, Single-pass type I membrane protein

CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD86
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 3.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene CD86
Gene Accession No. P42081, P42082
Gene Alias activation B7-2 antigen, B lymphocyte activation antigen B72, B7, B7.2, B70, B7-2, B-lymphocyte activation antigen B7-2, BU63, CD28 antigen ligand 2, Cd28l2, CD28LG2, CD86, CD86 antigen, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CD86 antigen precursor, CD86 molecule, CLS1, CTLA-4 counter-receptor B7.2, early T cell costimulatory molecule-1, early T-cell costimulatory molecule 1, Early T-cell co-stimulatory molecule 1, ETC-1, FUN-1, LAB72, Ly58, Ly-58, MB7, MB7-2, membrane glycoprotein, MGC34413, T-lymphocyte activation antigen CD86, TS/A-2
Gene Symbols CD86
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human CD86 (NP_7870584)
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12524, 942
Target Species Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.