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  6. Invitrogen™ CD88 (C5aR1) Monoclonal Antibody (20/70), Alexa Fluor™ 647, eBioscience™, Invitrogen™ 

Invitrogen™ CD88 (C5aR1) Monoclonal Antibody (20/70), Alexa Fluor™ 647, eBioscience™, Invitrogen™
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Catalog No. 51088282
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51-088-282 100 μg
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Catalog No. 51-088-282 Supplier Invitrogen™ Supplier No. 51088282
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Description

Rat Monoclonal Antibody

Description: This 20/70 monoclonal antibody recognizes mouse CD88 also known as C5aR1. CD88 is a complement receptor widely expressed on cells of the myeloid lineage. Clone 20/70 has been reported to block the binding of C5a to murine CD88. Applications Reported: This 20/70 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 20/70 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This may be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD88 (C5aR1)
Applications Flow Cytometry
Classification Monoclonal
Clone 20/70
Concentration 0.2 mg/mL
Conjugate Alexa Fluor 647
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene C5AR1
Gene Accession No. P30993
Gene Alias anaphylatoxin C5a receptor; C5A; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5AR; C5a-R; C5AR1; C5r1; Cd88; CD88 antigen; complement C5a receptor; complement C5a receptor 1; complement component 5 receptor 1; complement component 5, receptor 1; complement component 5a receptor 1; D7Msu1
Gene Symbols C5AR1
Host Species Rat
Immunogen RBL-2H3 transfected cells expressing murine C5aR.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12273
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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