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CD89 Monoclonal Antibody (MIP8a), Invitrogen™

Catalog No. PIMA528106
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500μg
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Catalog No. Quantity
PIMA528106 500μg
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Catalog No. PIMA528106 Supplier Thermo Scientific Supplier No. MA528106

Description

Mouse Monoclonal Antibody

This antibody recognizes the human CD89 cell surface antigen, a 50-75 kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R). CD89 is expressed by peripheral blood monocytes and neutrophils. MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD89
Applications ELISA, Flow Cytometry, Functional Assay, Immunoprecipitation
Classification Monoclonal
Clone MIP8a
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Fcar
Gene Accession No. P24071
Gene Alias CD89; CTB-61M7.2; Fc alpha receptor; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; FcalphaRI; FCAR; IgA Fc receptor; immunoglobulin A Fc receptor; immunoglobulin A Fc receptor transcript variant 1; immunoglobulin A Fc receptor transcript variant 3; immunoglobulin A Fc receptor transcript variant 7; immunoglobulin A Fc receptor transcript variant 9; immunoglobulin A Fc receptor transcript variant deltaEC1; immunoglobulin A Fc receptor transcript variant deltaEC1 delta TM/C; immunoglobulin alpha Fc receptor
Gene Symbols Fcar
Host Species Mouse
Immunogen Recombinant soluble human Fc alpha R
Purification Method purified
Quantity 500μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2204
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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