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CD8A Mouse anti-Human, Clone: OTI7C10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF802376

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).Specifications
CD8A | |
Monoclonal | |
Unconjugated | |
CD8A | |
CD8, Leu2, MAL, p32 | |
Mouse | |
Affinity Chromatography | |
RUO | |
925 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunohistochemistry (Paraffin), Western Blot | |
OTI7C10 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P01732 | |
CD8A | |
Human recombit protein fragment corresponding to amino acids 22-182 of human CD8A produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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