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MilliporeSigma™ CD8a, Mouse, FITC, Clone: RPA-T8,

Catalog No. MABF1673MI Shop All MilliporeSigma Products
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MABF1674MI 100 Tests
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Catalog No. MABF1673MI Supplier MilliporeSigma™ Supplier No. MABF1673
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Description

Mouse Monoclonal Antibody

The RPA-T8 antibody is specific for the 32-34kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The RPA-T8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. It is cross-reactive with CD8 in several non-human species, including Baboon, Chimpanzee, Cynomolgus and Rhesus. If used together with an alternative Anti-Human CD8a clone, Hit8a, the RPA-T8 antibody will not block binding of Hit8a to CD8a.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8a
Applications Flow Cytometry
Classification Monoclonal
Clone RPA-T8
Concentration Please refer to lot specific datasheet.
Conjugate FITC
Formulation Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Gene CD8A, MAL
Gene Accession No. P01732
Host Species Mouse
Immunogen Immunogen information for this antibody is proprietary information.
Purification Method Purified by size-exclusion chromatography
Quantity 25 Tests
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2°-8°C and protected from prolonged exposure to light. Do not freeze.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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