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Invitrogen™ CD8b Monoclonal Antibody (341), FITC
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Catalog No. PIMA544099
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Quantity:
100 μg
Catalog No. Quantity
PIMA544099 100 μg
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Catalog No. PIMA544099

Supplier: Invitrogen™ MA544099

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Description

Mouse Monoclonal Antibody

This antibody recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.

The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD8b
Applications Flow Cytometry
Classification Monoclonal
Clone 341
Concentration 0.5 mg/mL
Conjugate FITC
Formulation PBS with 15mM sodium azide; pH 7.4
Gene Cd8b
Gene Accession No. P05541
Gene Alias CD8; CD8 antigen 37 kDa chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8a; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; CD8B1; CD8beta; CD8BP; LEU2; Leu-2; LY3; Ly-3; Ly-C; Lymphocyte antigen 3; Lyt3; Lyt-3; MAL; OX-8 membrane antigen; p32; P37; T lymphocyte surface glycoprotein beta chain; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3
Gene Symbols Cd8b
Host Species Mouse
Immunogen CD8 positive Wistar rat splenic T cell hybridomas.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24931
Target Species Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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