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CD91 Mouse anti-Human, Brilliant Violet 510, Clone: A2MR-α2, BD Optibuild™

Catalog No. BDB743857 Shop All BD Biosciences Products
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BDB743857 50 μg
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Catalog No. BDB743857 Supplier BD Biosciences Supplier No. 743857
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Description

Mouse Monoclonal Antibody

The A2MR-α2 monoclonal antibody specifically reacts with a 600 kDa, type I membrane single protein, also known as theα2 Macroglobulin (α2M) receptor/low density lipoprotein receptor-related protein 1 (LRP-1). Reported to be an endocytic receptor involved with intracellular signalling, lipid homeostasis, clearance of apoptotic cells, andα2 Macroglobulin mediated clearance of secreted amyloid precursor protein found in Alzheimer patients. The single chain receptor undergoes cleavage, shortly after synthesis, into the 85 kDa transmembraneβchain that non-covalently binds to the extracellular 500-515 kDa a chain. It has a broad cellular distribution, but in the hematopoietic system it is expressed on monocyte lineage cells.α2M/LRP-1 mediates endocytosis of a variety of ligands includingα2M-proteinase complexes, plasminogen activators in complex with plasminogen activator inhibitor, or Pseudomonas /Exotoxin A. Ligand binding toα2M/LRP-1 is followed by rapid transport of the ligand to lysosomes for degradation.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD91
Classification Monoclonal
Clone A2MR-α2
Concentration 0.2mg/mL
Conjugate Brilliant Violet 510
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias A2MR, APOER, APR, IGFBP3R, TGFBR5, LRPA, LRP1
Host Species Mouse
Immunogen Purified Human α2 Macroglobulin
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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