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Description
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Specifications
Specifications
| Antigen | CD99 |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed) |
| Classification | Monoclonal |
| Clone | SPM586 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against native human CD99. |
| Dilution | Flow Cytometry (5-10 uL/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In 10mM PBS (0.05% BSA, 0.05% sodium azide). |
| Gene Alias | MIC2/MIC2X/MIC2Y |
| Gene Symbols | CD99 |
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