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Invitrogen™ Cdc20 Polyclonal Antibody
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Catalog No. PIPA534775
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100 μL
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PIPA534775 100 μL
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Catalog No. PIPA534775 Supplier Invitrogen™ Supplier No. PA534775
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, THP-1. Predicted reactivity: Mouse (94%), Rat (94%), Pig (97%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cdc20
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene CDC20
Gene Accession No. Q12834
Gene Alias 2310042N09Rik; bA276H19.3; C87100; cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55cdc; XELAEV_18025163mg; X-FZY
Gene Symbols CDC20
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human CDC20. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 991
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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