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CDC20Rabbit anti-Human, Polyclonal, Rockland™

Rabbit Polyclonal Antibody
Supplier: Rockland Immunochemicals 100401A17

Description
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This product reacts with human CDC20 (fizzy). Cross reactivity may also occur with CDC20 from other sources.
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.Specifications
CDC20 | |
Polyclonal | |
Unconjugated | |
CDC20 | |
2310042N09Rik; bA276H19.3; C87100; Cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; Cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55CDC; XELAEV_18025163mg; X-FZY | |
Rabbit | |
100 μL | |
Primary | |
Human | |
Antibody |
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot | |
85 mg/mL | |
Antibody with 0.01% sodium azide; pH | |
Q12834 | |
CDC20 | |
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 486-499 of Human CDC20 (fizzy) (C-terminal) coupled to KLH. | |
RUO | |
991 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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