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CDC20Rabbit anti-Human, Polyclonal, Rockland™
SDP

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 100401A17

Encompass_Preferred

Catalog No. 50-199-0102


May include imposed supplier surcharges.
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Description

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This product reacts with human CDC20 (fizzy). Cross reactivity may also occur with CDC20 from other sources.

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Specifications

Specifications

CDC20
Polyclonal
Unconjugated
CDC20
2310042N09Rik; bA276H19.3; C87100; Cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; Cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55CDC; XELAEV_18025163mg; X-FZY
Rabbit
100 μL
Primary
Human
Antibody
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
85 mg/mL
Antibody with 0.01% sodium azide; pH
Q12834
CDC20
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 486-499 of Human CDC20 (fizzy) (C-terminal) coupled to KLH.
RUO
991
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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