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CDC20Rabbit anti-Human, Polyclonal, Rockland™
SDP

Catalog No. 501990102
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100 μL
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50-199-0102 100 μL
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Catalog No. 50-199-0102 Supplier Rockland Immunochemicals Supplier No. 100401A17
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Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This product reacts with human CDC20 (fizzy). Cross reactivity may also occur with CDC20 from other sources.

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Specifications

Antigen CDC20
Applications ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 85 mg/mL
Conjugate Unconjugated
Formulation Antibody with 0.01% sodium azide; pH
Gene CDC20
Gene Accession No. Q12834
Gene Alias 2310042N09Rik; bA276H19.3; C87100; Cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; Cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55CDC; XELAEV_18025163mg; X-FZY
Gene Symbols CDC20
Host Species Rabbit
Immunogen This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 486-499 of Human CDC20 (fizzy) (C-terminal) coupled to KLH.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 991
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
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