Invitrogen™ Cdc23 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590232

Catalog No. PIPA590232

Description

Immunogen sequence: HSSKWSAELA FSLPALPLAE LQPPPPITEE DAQDMDAYTL AKAYFDVKEY DRAAHFLHGC NSKKAYFLYM YSRYLSGEKK KDDETVDSLG PLEKGQVKNE A; Positive Samples: U-87MG, 293T, HeLa, Jurkat, HepG2, NIH/3T3, mouse liver, mouse kidney, rat liver.

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.

Specifications

• Antigen: Cdc23
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cdc23
• Gene Alias: 6030435O18; ANAPC8; anaphase promoting complex subunit 8; anaphase-promoting complex subunit 8; APC8; CDC23; CDC23 (cell division cycle 23, yeast, homolog); CDC23 cell division cycle 23; cell division cycle 23; cell division cycle 23 homolog; cell division cycle protein 23; cell division cycle protein 23 homolog; CUT23; cyclosome subunit 8; D18Ertd243e; zgc:56013
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 291689, 52563, 8697
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.44 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BGZ4, Q9UJX2
• Gene Symbols: Cdc23
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CDC23 (NP_0046522).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG