Invitrogen™ Cdc23 Recombinant Rabbit Monoclonal Antibody (1Q2I3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538158

Catalog No. PIMA538158

Description

Positive Samples: HeLa, SKOV3, Jurkat, Mouse lung, Mouse brain, Mouse spleen, Rat brain Immunogen sequence: YSCGEIVEHL EESTAFRYLA QYYFKCKLWD EASTCAQKCC AFNDTREEGK ALLRQILQLR NQGETPTTEV PAPFFLPASL SANNTPTRRV SPLNLSSVTP.

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a 1755 amino acid protein that contains one UBR-type zinc finger and one RING-type zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. Mice lacking Ubr2 are infertile due to defects in male meiosis.

Specifications

• Antigen: Cdc23
• Classification: Recombinant Monoclonal
• Concentration: 1.55 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8BGZ4, Q9UJX2
• Gene Symbols: Cdc23
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 498-597 of human CDC23 (Q9UJX2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 1Q2I3
• Conjugate: Unconjugated
• Gene: Cdc23
• Gene Alias: 6030435O18; ANAPC8; anaphase promoting complex subunit 8; anaphase-promoting complex subunit 8; APC8; CDC23; CDC23 (cell division cycle 23, yeast, homolog); CDC23 cell division cycle 23; cell division cycle 23; cell division cycle 23 homolog; cell division cycle protein 23; cell division cycle protein 23 homolog; CUT23; cyclosome subunit 8; D18Ertd243e; zgc:56013
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 291689, 52563, 8697
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov