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Invitrogen™ Cdc27 Polyclonal Antibody
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Catalog No. PIPA596009
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100 μL
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PIPA596009 100 μL
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Catalog No. PIPA596009 Supplier Invitrogen™ Supplier No. PA596009
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HLQKDVALSV LSKDLTDMDK NSPEAWCAAG NCFSLQREHD IAIKFFQRAI QVDPNYAYAY TLLGHEFVLT EELDKALACF RNAIRVNPRH YNAWYGLGMI YYKQEKFSLA EMHFQKALDI NPQSSVLLCH IGVVQHALKK SEKALDTLNK AIVIDPKNPL CKFHRASVLF ANEKYKSALQ ELEELKQIVP KESLVYFLIG KVYKKLGQTH LALMNFSWAM DLDPKGANNQ IKEAIDKRYL PDDEEPITQE EQIMGTDESQ ESSMTDADDT QLHAAESDEF; Positive Samples: HeLa; Cellular Location: Nucleus.

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cdc27
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CDC27
Gene Accession No. A2A6Q5, P30260, Q4V8A2
Gene Alias AI452358; AN CDC27Hs; ANAPC3; anaphase promoting complex subunit 3; Anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; APC3; BC023187; cdc27; CDC27 homolog; cdc27.S; CDC27Hs; cell division cycle 27; cell division cycle 27 homolog; cell division cycle 27 homolog (S. cerevisiae); cell division cycle 27 S homeolog; cell division cycle protein 27 homolog; D0S1430E; D17S978E; HNUC; H-NUC; hypothetical protein; NUC2; nuc2 homolog; XELAEV_18046079mg
Gene Symbols CDC27
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 551-830 of human CDC27 (NP_0011075631).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 217232, 360643, 996
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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