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Invitrogen™ Cdc34 Polyclonal Antibody
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Catalog No. PIPA123184
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100 μL
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PIPA123184 100 μL
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Catalog No. PIPA123184 Supplier Invitrogen™ Supplier No. PA123184
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Description

Mouse Polyclonal Antibody

Recommended positive controls: 293.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF (FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF (SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cdc34
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with no preservative
Gene CDC34
Gene Accession No. P49427
Gene Alias (E3-independent) E2 ubiquitin-conjugating enzyme R1; AI327276; CDC34; cell division cycle 34; cell division cycle 34 homolog; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; serine protease; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin conjugating enzyme E2 R1; ubiquitin-conjugating enzyme Cdc34; ubiquitin-conjugating enzyme E2 R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1
Gene Symbols CDC34
Host Species Mouse
Immunogen Full-length human Cdc34 expressed in E. coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 997
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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