CDC37 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-6123	150 μL

Catalog No. 50-172-6123 Supplier Proteintech Group Inc Supplier No. 102181AP150UL

Description

Rabbit Polyclonal Antibody

In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK′s). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck and Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.

Specifications

• Antigen: CDC37
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: CDC37
• Gene Accession No.: Q16543, Q61081, Q63692
• Gene Alias: CDC37, CDC37A, Hsp90 co chaperone Cdc37, P50CDC37
• Gene Symbols: Cdc37
• Host Species: Rabbit
• Immunogen: CDC37 Fusion Protein Ag0267
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11140, 114562, 12539
• Target Species: Human, Mouse, Non-human Primate, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG