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MilliporeSigma™ CDC45, Rabbit, Unlabeled, Polyclonal,

Catalog No. ABC962MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
ABC962MI 100 μL Unconjugated
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Catalog No. ABC962MI Supplier MilliporeSigma™ Supplier No. ABC962
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Description

Rabbit Polyclonal Antibody

Cell division control protein 45 homolog (UniProt O75419; also known as PORC-PI-1) is encoded by the CDC45 (also known as CDC45L, CDC45L2, UNQ374/PRO710) gene (Gene ID 8318) in human. Recruitment of replication initiation proteins at the G1/S transition enables origin DNA unwinding and loading of DNA polymerases. CDC45 is a replication initiation protein that plays an essential role in the establishment and progression of the replication fork. Cdc45 associates with the heterohexameric Mcm2-7 helicase and the GINS complex (go-ichi-nii-san, Japanese for 5-1-2-3, for the subunits Sld5, Psf1, Psf2 and Pfs3) to form the CMG (Cdc45-Mcm2-7-GINS) complex. CMG represents the eukaryotic replicative DNA helicase that unwinds origins of replication and drives the replication fork. CDC45 is also reported to interact with several other replication proteins, including DNA helicase B (DHB), Mcm10, Orc2, TopPB1, and DNA polymerases alpha, delta and epsilon.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CDC45
Applications Western Blot
Classification Polyclonal
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene CDC45, CDC45L, CDC45L2, UNQ374/PRO710
Gene Accession No. O75419
Host Species Rabbit
Immunogen GST-tagged recombinant human CDC45 C-terminal fragment.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Apoptosis & Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_003495
Test Specificity This polyclonal antibody detects CDC45 C-terminal region highly conserved among human, mouse, rat, and hamster species.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
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For Research Use Only. Not for use in diagnostic procedures.

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